As xld said, you can't auto-enable the macros due to security reasons. Similarly, you can't set it to be in "Design mode". (Incidentally, macros themselves don't care about design mode. You can add buttons via VB w/o being in "Design mode") To start on Sheet 1, cell A1 always, you can put this in the ThisWorkbook module.
[pre]
Code:
Private Sub Workbook_Open()
Worksheets("Sheet1").Range("A1").Select
End Sub