P I am pretty sure VB is available for all the ms office products and this would give you the interactivity but it would be a steep learning curve unless you are right into excel vba already. You should goggle VB dor ms PowerPoint to go further.
I don't know the answer, but I think maybe you can't interact with the spreadsheet, particularly in slideshow view. I am "mostly guessing" though You could be asking in the wrong forum.